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HAppyCross™ contains high concentration of hyaluronic acid (1.6%) i.e. 35.2 mg/syringe. Cross-linked Hyaluronic Acid. HAppyCross™ is a cross-linked hyaluronic acid gel with high degree of cross-linking (85%). Cross-linking: • Ensures a gel-like rheological behavior, maximizing then the mechanical properties of hyaluronic acid HAppyCross™ is a cross-linked hyaluronic acid gel (IPN-Like technology). Cross-linking: Ensures a gel-like rheological behaviour, maximizing then the mechanical properties of hyaluronic acid. Increases the residence time of the gel in the joint cavity, preventing biodegradation from free radicals and enzymes HAppyCross is a cross-linked hyaluronic acid gel (IPN-Like technology). Cross-linking: Ensures a gel-like rheological behaviour, maximizing then the mechanical properties of hyaluronic acid. Increases the residence time of the gel in the joint cavity, preventing biodegradation from free radicals and enzymes
Product description. Flawless Achéve Cross-linked Hyaluronic Acid: -Great for anti-aging, deep moisturizing, deep wrinkle. repair. -Keeps the skin moist hydrated. -Stimulates collagen assisting the formation. of new tissue growth. About The Product: -This product is cross-linked hyaluronic acid and non-animal A NEW SYSTEM OF TRANSDERMIC DELIVERY MADE UP OF CROSS-LINKED HYALURONIC ACID. With age, skin becomes more susceptible to wrinkles and sagging. Exposure to damaging sun rays and years of muscle movement (squinting, chewing, smiling) contribute to the breakdown of tissue and loss of volume in the skin
In addition to radicular symptoms, the formation of scar tissue may cause problems during reoperation. The authors aimed to investigate the effects of cross-linked high-molecular-weight hyaluronic acid (HA), an HA derivative known as HA gel, on the prevention of epidural fibrosis by using histopathological and biochemical parameters 5ml Cross Linked Hyaluronic Acid Dermal Fillers Breast filler injection hyaluronic acid nose filler Product DescriptionHyaluronic Acid filler is a injectable long-lasting dermal filler Hyaluronic acid (HA) is a natural element of our body and fulfils important functions such as maintaining moisture, firmness and elasticity in the skin. Environmental factors such as excessive and intensive sun exposure, and the natural ageing process contribute to the depletion in the body's own level of hyaluronic acid
Hyaluronic Acid what the difference cross-linked /vs / non cross - linked. This is for information only. Not available in Canada. This device is not listed w.. Efficacy of eyedrops containing cross-linked hyaluronic acid and coenzyme Q10 in treating patients with mild to moderate dry eye Eur J Ophthalmol. 2018 Jan;28(1):25-31. doi: 10.5301/ejo.5001011. Epub 2018 Feb 19. Authors Elisa I Postorino 1. A new dermal filler made of cross-linked and auto-cross-linked hyaluronic acid in the correction of facial aging defects. Sparavigna A(1), Fino P, Tenconi B, Giordan N, Amorosi V, Scuderi N. Author information: (1)Derming, Clinical Research and Bioengineering Institute, Monza, MB, Italy HA has the incredible capacity to attract and hold onto 1000x its weight in moisture. And here lies the key: Hyaluronic acid should be used in a moisturizer in order for it to work—when you add moisture to the skin, you're giving the HA added water to absorb and hold onto, rather than pulling moisture out of dry skin. Rather, the HA brings moisture to the surface of the skin and holds it. Hyaluronic acid is formed by streptococci bacterial fermentation. The products in the VYCROSS® Collection are manufactured using Allergan's proprietary VYCROSS technology - cross-linking the hyaluronic acid molecules to create a smoother, more efficient filler that allows for a lower concentration of hyaluronic acid to be used
Advanced Collagen Supplement, Type 1, 2 and 3 with Hyaluronic Acid and Vitamin C - Anti Aging Joint Formula - Boosts Hair, Nails and Skin Health - 120 Capsules - by ForestLeaf. 120 Count (Pack of 1) 4.5 out of 5 stars. 8,634. $19.95 Non-cross linked hyaluronic acid 'flows' in the dermis which plumps up the skin and softens lines , but when injected, it does not 'stay put' at the site of injection. Whereas with cross-linked hyaluronic acid, it has a chemical preservative called bdde that allows for the hyaluronic acid to fill the area and 'stay in the place' of injection Hyaluronic acid (HA), along with its cousin sodium hyaluronate, is an immensely popular ingredient in skincare and makeup. It's also naturally found in the body. Most of it dwells in the extracellular matrix, the scaffold which holds up the cells of your skin. Hyaluronic acid is found in both the epidermis and the deeper dermis, where it's.
A method for producing cross-linked hyaluronic acid comprising cross-linking one or more polymers at a low temperature from 10 to 30 °C for a reaction time greater than 48 hours under basic condition with a cross-linking agent to form a cross-linked hyaluronic acid, wherein the polymer is selected from the group consisting of hyaluronic acid, hyaluronate, derivatives thereof and a mixture. Background: This randomized, double-blind, multi-center, non-inferiority trial was conducted to assess the efficacy and safety of a cross-linked hyaluronate (XLHA, single injection form) compared with a linear high molecular hyaluronate (HMWHA, thrice injection form) in patients with symptomatic knee osteoarthritis. Methods: Two hundred eighty seven patients with osteoarthritis (Kellgren.
Simple, non-surgical cosmetic treatment administered by fully qualified G Injectable dual cross-linked adhesive hyaluronic acid multifunctional hydrogel scaffolds for potential applications in cartilage repair However, injectable hyaluronic acid (HA) hydrogels have limited applications in cartilage tissue engineering due to their poor mechanical properties and fast enzymatic degradation. In this study, a double. HA fillers like Juvederm and Restylane are cross linked. In hyaluronic acid's natural form, the substance is a liquid which the body metabolizes in about half a day. Cross linking is a process that chemically binds the individual chains of the acid so that it is changed into a gel that lasts much longer once injected inside facial tissue
hyaluronic acid for patients with symptomatic osteoarthritis of the knee, based on moderate-high quality evidence. The 2014 guidelines on osteoarthritis from the National Institute for Health and Care Excellence (NICE) conclude more strongly, Do not offer intra-articular hyaluronan injections for the management of osteoarthritis Chiara Posarelli, Andrea Passani, Marzia Del Re, Stefano Fogli, Mario Damiano Toro, Antonio Ferreras, Michele Figus, Cross-Linked Hyaluronic Acid as Tear Film Substitute, Journal of Ocular Pharmacology and Therapeutics, 10.1089/jop.2018.0151, (2019) ReNice Injectable filler (injectable cosmetic filler, injectable facial filler) is a soft tissue filler injected into the skin to help fill in facial wrinkle.. , deep and low molecular Hyaluronic Acid Powder, why don't doctors consider purchasing at a fraction of the cost to make their own injectable syringes? Steril syringes, Proper HA molecular density depending on the area to be injected, and distilled water alone or Bacteriostatic water
Reflections on which hyaluronic acid to use in the Hyaluronic pen. Hyaluronic acid is a water-soluble molecule. It can have a more or less high molecular weight in compositions called fillers depending on how tied or not it is, or rather CROSS-LINKED. The greater the cross-linking, the greater the volume occupied by hyaluronic acid in space Hyaluronic acid, also called hyaluronan, is naturally produced by the human body and is an essential component in skin hydration. It can also be found in skin care products, dermal fillers and supplements. Replenishing the skin with hyaluronic acid is effective in combating the natural aging process Across, 2016. REVOLAX cross linked hyaluronic acid dermal filler. Facial Aesthetics Market to 2020 GBI Research. Funt, D, 2013. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clinical,Cosmetic and Investigational Dermatology, Vol 6, 295-316. Across, 2007. Firm and lasting Hyaluronic acid filler Revolax BACKGROUND. Hyaluronic acid (HA)-based dermal fillers are the most commonly used fillers in the aesthetics market.1 A glycosaminoglycan and a chief component of the extracellular matrix, HA is mainly responsible for maintaining hydration in the dermis. HA is a linear polysaccharide chain with the alternating monosaccharides d-glucuronic acid and N-acetyl-d-glucosamine. Side effects of hyaluronic acid. If the hyaluronic acid in supplements is being absorbed, in theory there are several adverse reactions that may result: 1. May promote cancer growth. Higher amounts of hyaluronic acid correlate with malignancy and severity for certain types of cancer
The Inkey List Hyaluronic Acid Serum. At just $8, The Inkey List's Hyaluronic Acid Serum is a total steal. Slather a dime-sized dose of this weightless formula on whenever your skin is feeling dry. . 1 In the 34-month retrospective chart review, 15 neuropathic pain patients (7 women, 8 men) with 22 pain syndromes were studied. The average age of the patients.
Fosyderm hyaluronic acid dermal filler is in the cortex to fill the pits and wrinkles.The surface of skin is to restore full state, immediately smooth wrinkles.People immediately have a youthful natural beauty. Applicable scope: forehead lines and lines between the eyebrows, eyes, lips, tiger lines and lines. 3 Glamour soft Hyaluronic Acid for hyaluron pen and needle injection use. It is made in Korea with Korean KFDA & GMP Certification. Glamour overcomes the limit of original structure of hyaluronic acid to develop a mesh cross linking morphological technique Hyaluronic acid (HA) was chemically crosslinked with glutaraldehyde (GA) to produce water-insoluble films having low water contents when brought into contact with water. The crosslinking reaction. HA Gel Filler Gel Hyaluronic Acid Injection 10ml Sub Skin Factory shipment, support OEM, sincerely recruit agents, prices can be negotiated. Hyaluronic acid (HA) is a member of the glycos amino glycan (GAG) family and is naturally present in our body. It is located within our cartilage, connective tissue, joint flui
Register for a webinar about hyaluronic acid products for knee injections. As BCBS of Michigan communicated previously, starting Jan. 1, 2020, Blue Cross Blue Shield of Michigan and Blue Care Network will consider some hyaluronic acid drugs to be preferred or covered and others to be nonpreferred or noncovered Hyaluronic Acid (HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. HA is a polymer of disaccharides, themselves composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3 glycosidic bonds Fosyderm Hyaluronic Acid filler is a injectable long-lasting dermal filler. It is cross-linked, reabsorbable, non-animal source hyaluronic acid that exists naturally in the body. Our product is a gel-like substance that is injected into the skin to fill deep wrinkles and restore volume Sterile gel comprising physiological crystal clear - devoid of cross-linking agent BDDE cross-linked hyaluronic acid. The product is packed in sterile form of a pre-filled syringe provided with two needles UTA. UTA needle has a greater bandwidth, which increases the fluidity of injection and allows for a reduction in pressure on the piston 35.
Restylane. Restylane is a stabilized, lower-molecular-weight, partially cross-linked hyaluronic acid that has been approved by the U.S. Food and Drug Administration (FDA) for soft tissue augmentation. From: Clinical Review of Oral and Maxillofacial Surgery (Second Edition), 2014. Download as PDF. About this page Glamour HA Shine skin booster. Multi cross linked hyaluronic acid has fifty times the water-binding capacity of natural hyaluronic acid! And that means skin is continuously hydrated, plump and healthy with long sustainability. It can protect skin while keeping it hydrated. This is the key for anti-aging, and healthy, supple skin Low Mw thiolated hyaluronic acid (HA-SH-Low Mw) Thiolated Gelatin type B (Gel-SH) Methacrylated hyaluronic acid (HA-MA) The substitution degree of functional group can be adjusted which can regulate the crosslinking degree, gelation time and stiffness of the hydrogel. Soft Type Materials: Gelation systems: 1. Chemical Cross linking Hydrogel System Profhilo is the one of the most talked about injectable treatments in Europe right now. Named the anti-wrinkle treatment of 2019, Profhilo is a new treatment for rejuvenating skin hydration, elasticity and quality. Like Restylane skinboosters and many other dermal fillers, the main ingredient is Hyaluronic Acid (HA).However, Profhilo has many interesting differences compared to other HA. . Juvederm Ultra Plus XC contains 0.3% lidocaine. Same as above. Same as above. Same as above. Injected into mid-to-deep dermis. Approximately 6-12 months. 20 mL/60 kg (130 lb) body mass per year. Juvederm Voluma X
Description. CE Certified Product Check all CE certifies Products HERE. Ammi is a line of fillers based on hyaluronic acid created by South Korean company. The company produces world class products with hyaluronic acid.It produces various fillers and cosmetics with hyaluronic acid using its unique, state-of-the-art NMC Technology (Nano-Mesh Cross-Linking) What is hyaluronic acid: Hyaluronic Acid (HA) is found in many commercial topical tear film replacement therapies. It is a high molecular weight glycosaminoglycan that is naturally occurring in the body that helps support the wound healing process. HA has been found to have ameliorative effects in cases of keratoconjunctivitis sicca (KCS)1 Hyaluronic Acid and BDDE. Up to 18 months. Yes. $400 - $800 per 1 ml syringe. 20 mg/ml. Under the muscle under the eye to restore volume; NLF, Marionette lines; lips. None/rare** Restylane Refyne. Dissolvable, homogenous HA gel, non-hydrophilic, XpresHAn cross-linking. Hyaluronic Acid and BDDE. Up to 12 months. Yes. $400 - $800 per 1 ml syringe. 9. Colen S, van den Bekerom MP, Mulier M, et al. Hyaluronic acid in the treatment of knee osteoarthritis: a systematic review and meta-analysis with emphasis on the efficacy of different products. BioDrugs. Aug 1 2012;26(4):257-268. PMID 22734561 10. Miller LE, Block JE. US-approved intra-articular hyaluronic acid injections are safe and.
Hyaluronic acid derivatives may be considered medically necessary for the treatment of osteoarthritis of the knee and if the conditions indicated below are met. Hyaluronic acid derivatives may be considered investigational for all other indications. Prior-Approval Requirements Age 18 years or older (22 or older for Synvisc, Synvisc-One, and. Injection of Cross-Linked Hyaluronic Acid. Step 3a. For the dorsal cutaneous nerve branches of T11-L5, slowly insert a 1½-inch, 25G hypodermic needle perpendicularly through the skin wheal until it encounters tissue resistance. At that point, with the opposite hand, fix the hub of the needle to lock its position in place (see Figure G), and. Penis, Breast Enhancement, Beauty Products manufacturer / supplier in China, offering 20ml Cross-Linked Injections Penis Enlargement Ha Hyaluronic Acid Injection, Skinject 20ml Sub-Skin Hyaluronic Acid Dermal Filler Breast Enlaigement Buttock Dermal Filler Penis Filler, Skinject 2ml Deep Filler Skin Care Ha Injectable Hyaluronic Acid Dermal Fillers for Face Chin Nose Plastic Surgery and so on The Power of RevitaLift® Volume Filler. As you age, skin starts to lose volume as levels of naturally-occurring Hyaluronic Acid are depleted in the epidermis, the uppermost layer of the skin. Hyaluronic Acid functions to help skin maintain volume and moisture. Depleted levels lead to loss of skin's volume, and in turn, fine line and wrinkles
Helps maintain natural skin moisture and elasticity. Vegan food supplement cross-linked HA. Seikagaku's proprietary photo-gelation technology creates very large molecules that may greatly increase the total residence time of hyaluronic acid in the joint and surrounding tissues. Joint residence time is a measure of the total time from injection that a product can be detected in any part of the knee
It is a cross-linked hyaluronate, which is also referred to as hyaluronan, hyaluronic acid, or HA. Gel-One Hyaluronate originates from an avian source (highly purified, from chicken combs). In processing, polysaccharide chains are part of the creation of the Gel-One Hyaluronate cross-linked polymer.The viscoelastic properties of this hydrogel. Non Cross Linked Hyaluronic Acid Gel. . Daytona® Pure has a specific purpose - to provide deep hydration and restore youthfulness to skin by re-growing your own natural collagen. Daytona® Pure is quickly absorbed into the skin, and restores a more youthful appearance that time and exposure to elements have taken from your skin The Cross Linked Hyaluronic Acid Dermal Filler is a sterile injectable, pyrogen-free gel, which is composed of a cross-linked hyaluronic acid from a non-animal origin in a phosphate buffer saline solution. The gel is latex free, viscoelastic, clear, colorless and biodegradable Only a few left! HydroLift: Non-crosslinked Hyaluronic Acid Solution -10ml vial. $25.00. $25.00. Disposable Ampule for the Mesotherapy / Hyaluronic Gun or Hyaluron Pen Ampoule (0.3mL) $40.50 - $215.00. $40.50 - $215.00. HydroLift Kit: Non-Crosslinked HA Solution (6 vials), Hyaluronic Pen, 15 Ampules & Free Online HydroLift Training Course with.
. This naturally occurring hyaluronic acid degrades quickly, in 24-48 hours. Restylane dermal fillers contain hyaluronic acid that has been stabilized with a cross-linking technology. This makes the chains of the hyaluronic acid molecules form a three-dimensional network that is. Abstract. Hyaluronic acid (HA) was chemically cross-linked with poly (ethylene glycol) diglycidyl ether, a diepoxy compound (EX-810), to yield low water content and slowly degradable films when brought into contact with water. The cross-linking reaction was performed under acidic and neutral conditions, since the epoxy group is readily. Hyaluronic Acid Gel seems to be the big craze now. The Hyaluron pen has given the beauty industry an opportunity to provide services at the fraction of the cost compared to recent Medical services that are costly for the average consumer. It has also brought a safer solution to needle injections
Hyaluronan Injections in joints other than the Knee (DRUG.00017) Medical policy DRUG.00017 addresses the use of injections of hyaluronan in joints other than the knee, including osteoarthritis and temporomandibular joint disease. This therapy may also be referred to as viscosupplementation and cross-linking parameters in hyaluronic acid hydrogels—Deﬁnitions Hyaluronic acid (HA, also known as hyaluronan) is a linear polysaccharide (Fig. 1) naturally occurring in mammalian tissues (Laurent & Fraser, 1992). It consists of a repeating disaccharide Cross-linked hyaluronic acid is a great treatment method because it augments and sustains many times over the restorative and healing process of the body including: 1.Anti-inflammatory response. 2.Inhibition of scar formation; 3.Entry into the healing and restoration phas
The hyaluronic acid powder with an average molecular weight 1,000,000 Da was obtained from Vivatis Pharma (Hamburg, Germany). The chemical cross-linker 1,4-butanediol diglycidyl ether (BDDE) and the enzyme bovine testicular hyaluronidase BTH powder (3000 U/mg) were purchased from Sigma-Aldrich Co (St. Louis, Missouri, USA) Hyaluronic Acid is a naturally occurring substance that is found throughout the body's cells. Clusters are found most densely in the skin but also occurs in cartilage, connective tissue and fluid that lubricates the joints. As a highly soluble substance, Hyaluronic Acid can hold up to 1000 times its weight in H20 molecules Hyaluronic acid (HA) is a natural polyelectrolyte abundant in mammalian connective tissues, such as cartilage and skin. Both endogenous and exogenous HA produced by fermentation have similar. Intraarticular Injections of Steroids, Hyaluronic Acid or Platelet Rich Plasma Versus Placebo for the Knee Osteoarthritis 240 Nov 2020 (recruiting) NCT04204265a A Prospective Study of a Single Injection Cross-linked Sodium Hyaluronate (MONOVISC) to Provide Symptomatic Relief of Osteoarthritis of Shoulder Joint 25 Mar 2021 (recruiting) NCT04204278 Namely, the Hyaluronic Acid the human body produces has a pretty short lifespan (around 2-4 days), however the Hyaluronic Acid inside the carrier that you are able to treat the Dermis with can last for months (more specifically 3-6 months, usually, when it comes to fillers that can be inserted into Demis)
Elasty Deep. Elasty, manufactured by the South Korean company Dongbang Medical, is a cross-linked hyaluronic acid filler which is great for to be used on the cheek, perioral and for battling deep facial wrinkles. The injection depth for Elasty Deep is the stubbornness lower or subcutaneous layer. Other products are Elasty Fine, Elasty Grand. A homogeneous cross-linked hydrogel consisting of monophasic Hyaluronic acid and PEG-polymer chains (IPN-technology). OVERVIEW The filler which combines the immediate filling effect of 3-DHA hydrogel with the collagen-stimulating effect of CaHA The present invention relates to a process for the preparation of modified hyaluronic acid (HA), in particular cross-linked HA, for use in cosmetic, biomedical and pharmaceutical applications. Hyaluronic acid (HA) is a natural and linear carbohydrate polymer belonging to the class of the non-sulfated glycosaminoglycans. It is composed of beta-1. Anthem Blue Cross is the trade name of Blue Cross of California. Anthem Blue Cross and Anthem Buel Cross Life and Health Insurance Company are J3490 Hyaluronic acid gel Juvederm J3490 Romosozumab-aqqg Evenity (PA effective 12/1/19) J3490 Sarilumab Kevzara J3490 Leuprolide susp/norethindone tablet Lupaneta Pack (reviewed for NON -oncologic. LG Chem has studied hyaluronic acid products since 1990. It launched solutions used for ophthalmic surgery in 1995, and a drug for osteoarthritis in 2005, using hyaluronic acid ingredients. With the accumulated knowledge, LG Chem launched the first Korean hyaluronic acid filler, 'Yvoire Classic,' in the Korean aesthetic market
The different variations of the gel calibration and different degrees of cross linking around this constant hyaluronic acid concentration gives way to the optimal gel texture of EMERVEL. Thicker or thinner fillers were obtained thanks to varying gel calibration, firmer or softer fillers were obtained thanks to varying cross-linking High quality fillers around mouth area beauty injections fillers non cross linked ha filler BEUFILLER Injectable hyaluronic acid filler Type Derm Derm Deep Derm Plus Composition 20mg/ml 20mg/ml 20mg/ml Approximate number of gel particles ml 100,000 10,000 5,000 Particle size(mm) 0.15 -0.28 0.28 -0.5 0.5 -1.25 Recommended indications Moderate wrinkles, such as glabellar,oral commissures, Lips. A randomized, controlled, single masked study, was performed in 40 patients affected by mild to moderate DED, to evaluate efficacy and safety of a collyrium based on cross-linked hyaluronic acid (XLHA) added with Coenzyme Q10 (CoQ10) in comparison to an eye drop considered a gold standard for tear substitutes, based on hyaluronic acid (HA) 0.15% Hyaluronic acid sodium salt (HA) and auto cross-linked polymer (ACP) sodium salt were provided by Fidia Farmaceutici S.p.A (Abano Terme, Italy). Bovine testes hyaluronidase (BTH; EC 188.8.131.52) was purchased from the European Directorate for the Quality of Medicines & Figure 1. (a) Scheme of HBC synthesis and purification
GANA HA Type A is a top-performing dermal filler that is specially developed to deliver long-lasting large volume facial contouring and augmentation without surgery or any other invasive procedure. Thanks to its high cross-linking ratio, impressive concentration of Hyaluronic Acid and unmatched viscosity, it is among the best volumizing filler injections currently available on My Lip Filler. Multi cross linked hyaluronic acid has fifty times the water-binding capacity of natural hyaluronic acid! And that means skin is continuously hydrated, plump and healthy with long sustainability. It can protect skin while keeping it hydrated. This is the key for anti-aging, and healthy, supple skin.. It has been manufactured by cross-linking 3D technology and it's high volumetric properties enable resistance to biodegradation. Benefits of Neuramis Deep Lido: Neuramis Deep Lidocaine contains purified Hyaluronic Acid which has excellent anti-wrinkles abilities as it hydrates and retains moisture in the skin Hyaluronic acid is a natural, gel-like substance in your joints. It cushions and lubricates your joints as you move them. If you develop OA, cartilage in your joint breaks down and wears away. OA. Hyaluronic Acid Synvisc-One (J7325) Remicade ® agent is preferred product In the February 2017 edition of the Network Update, we announced Anthem Blue Cross and Blue Shield (Anthem) selected Remicade (infliximab) to be the infliximab of choic
Introduction. Hyaluronic acid (HA)-based fillers are the most common and popular dermal fillers used for esthetic purpose. 1 Such dermal fillers are hydrogels, usually composed of >95% of water and 0.5-3% of HA which gives them a gel-like structure. 2 HA is a polysaccharide, which is one of the major constituents of the extracellular matrix in vertebrates Commercially available hyaluronic acid gel fillers are manufactured in a medical facility via streptococcus biofermentation and are made to last longer by the addition of stronger bonds between the molecules. These bonds are referred to as cross-linking and can consist of divinyl sulfone or butanediol diglycidyl ether (BDDE) for example XCELENS EXTRA 4 is developed to fill deep and middle wrinkles, chin and cheeks area, jaw contour and small depressed areas. Extra 4 has an volumizing effect for lips acting on the deep line and wrinkles. Monophasic crosslinked hyaluronic acid BDDE 23 mg / ml + Lidocaine 0.3% of very high molecular weight and crosslinking 5/5. Mix cross and non cross linked HA